PERCUTANEOUS-ABSORPTION OF A CHLORHEXIDINE DIGLUCONATE SOLUTION

Authors
LAFFORGUE C CARRET L FALSON F REVERDY ME FRENEY J
Citation
C. Lafforgue et al., PERCUTANEOUS-ABSORPTION OF A CHLORHEXIDINE DIGLUCONATE SOLUTION, International journal of pharmaceutics, 147(2), 1997, pp. 243-246
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
147
Issue
2
Year of publication
1997
Pages
243 - 246
Database
ISI
SICI code
0378-5173(1997)147:2<243:POACDS>2.0.ZU;2-J
Abstract
Chlorhexidine is an antiseptic widely used to clean the skin. The pres ent work compare the percutaneous diffusion of Hibitane(R) through hai rless rat skin with or without stratum corneum. For the tests carried out on whole skin, the storage is more important than the diffusion; t he reverse was observed for stripped skin. The results are discussed a ccording the composition of the commercial solution and the physicoche mical characteristics of chlorhexidine digluconate. (C) 1997 Elsevier Science B.V.