Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent

Citation
M. Sweeney et al., Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent, J APP PHYSL, 85(6), 1998, pp. 2040-2046
Citations number
29
Categorie Soggetti
Physiology
Journal title
JOURNAL OF APPLIED PHYSIOLOGY
ISSN journal
87507587 → ACNP
Volume
85
Issue
6
Year of publication
1998
Pages
2040 - 2046
Database
ISI
SICI code
8750-7587(199812)85:6<2040:EOCIPA>2.0.ZU;2-I
Abstract
We examined the changes in isolated pulmonary artery (PA) wall tension on s witching from control conditions (pH 7.38 +/- 0.01, PCO2 32.9 +/- 0.4 Torr) to isohydric hypercapnia (pH change 0.00 +/- 0.01, PCO2 change 24.9 +/- 1. 1 Torr) or normocapnic acidosis (pH change -0.28 +/- 0.01, PCO2 change -0.3 +/- 0.04 Torr) and the role of the endothelium in these responses. In rat PA, submaximally contracted with phenylephrine, isohydric hypercapnia did n ot cause a significant change in mean(+/- SE) tension [3.0 +/- 1.8% maximal phenylephrine-induced tension (P-o)]. Endothelial removal did not alter th is response. In aortic preparations, isohydric hypercapnia caused significa nt (P < 0.01) relaxation (-27.4 +/- 3.2% P-o), which was largely endotheliu m dependent. Normocapnic acidosis caused relaxation of PA (-20.2 +/- 2.6% P -o), which was less (P < 0.01) than that observed in aortic preparations (- 35.7 +/- 3.4% P-o). Endothelial removal left the pulmonary response unchang ed while increasing (P < 0.01) the aortic relaxation (-53.1 +/- 4.4% P-o). These data show that isohydric hypercapnia does not alter PA tone. Reductio n of PA tone in normocapnic acidosis is endothelium independent and substan tially less than that of systemic vessels.