A mutant of Mycobacterium smegmatis defective in dipeptide transport

Authors
Bhatt, A Green, R Coles, R Condon, M Connell, ND
Citation
A. Bhatt et al., A mutant of Mycobacterium smegmatis defective in dipeptide transport, J BACT, 180(24), 1998, pp. 6773-6775
Citations number
19
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
180
Issue
24
Year of publication
1998
Pages
6773 - 6775
Database
ISI
SICI code
0021-9193(199812)180:24<6773:AMOMSD>2.0.ZU;2-P
Abstract
A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine ( beta-alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on beta-Ala and/or L-His were similar in the mutant and the wild type. However, the mutant showed signifi cant impairment in the uptake of carnosine. This study is the first descrip tion of a peptide utilization mutant of a mycobacterium.