L. Overgaard et al., Anti-inflammatory properties of titanium in sd the joint environment - An experimental study in rats, J BONE-BR V, 80B(5), 1998, pp. 888-893
Citations number
29
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine","da verificare
Little is known about the tissue reactions to various implant materials whi
ch coincide with an inflammatory reaction. We used the avridine arthritis r
at model to evaluate the tissue response in the synovial, interstitial and
subcutaneous tissues after implant insertion.
Quantitative immunohistochemistry showed that normal joint synovial tissue
is dominated by ED2-positive resident macrophages. Polyethylene implants in
duced a much stronger foreign-body reaction than titanium implants, as meas
ured by the number of interfacial ED1-positive macrophages. The tissue resp
onse to titanium and polyethylene was also vastly different in arthritic sy
novial tissue compared with control tissue.
It is likely that these biomaterials interact differently with inflammatory
cells or intermediary compounds. It may be that arthritic synovial tissue
produces reactive oxygen intermediates (free radicals) with which titanium
has a unique anti-inflammatory interaction in vitro.