F. Gruber et al., Azithromycin compared with minocycline in the treatment of acne comedonicaand papulo-pustulosa, J CHEMOTHER, 10(6), 1998, pp. 469-473
This open study was conducted in 72 outpatients with acne vulgaris, to comp
are the clinical efficacy and tolerability of azithromycin and minocycline.
Azithromycin was administered as a single oral dose (500 mg/day) for 4 day
s in four cycles every 10 days and minocycline was administered 100 mg dail
y for 6 weeks. improvement was assessed 6 weeks after initiation of treatme
nt with a four-graded scale. A satisfactory clinical response was observed
in 75.8% of the patients treated with azithromycin and in 70.5% of those tr
eated with minocycline. There were no significant differences between these
two acne treatments in terms of reduction of the number of lesions (p > 0.
05). Both agents were well tolerated and mild side effects were reported in
10.3% of azithromycin and 11.7% of minocycline treated patients. We conclu
de that azithromycin is at least as clinically effective and well tolerated
as minocycline as treatment of facial comedonic and papulopustular acne.