Long term treatment with clarithromycin for cryptosporidiosis and emergence of drug resistant disseminated infection due to Mycobacterium avium: Casereport

Macrolide resistance in disseminated Mycobacterium avium infection is of ma jor concern in AIDS patients as these drugs represent the main component of combination therapy. Clarithromycin and azithromycin should not be used al one for the treatment and prophylaxis of the disease because of the risk of selecting resistant strains. We report the case of a clarithromycin resist ant disseminated M, avium infection in an AIDS patient, acquired after long term monotherapy with clarithromycin for the treatment of cryptosporidiosi s.