Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: marked tumor necrosis, but no survival benefit?

Background/Aims: Hepatic artery chemoembolization was introduced in the tre atment of patients with unresectable hepatocellular carcinoma waiting for l iver transplantation. The rationale for this preoperative treatment was to control tumor growth during the waiting period and to improve long-term sur vival. This study aimed to investigate whether preoperative chemoembolizati on not only induces marked tumor necrosis but also has a survival benefit. Methods: In this study 21 patients with hepatocellular carcinoma who underw ent pretransplant chemoembolization (group I) were compared with 21 histori cal control patients (group II) without preoperative chemoembolization in a case-control study. The number of pretransplant chemoembolizations in each patient in group I varied between 1 and 5 with a mean of 2.44 +/- 1.15. In addition, six patients of this group received preoperative systemic chemot herapy. Results: Overall, there were no differences in survival between the groups with and without pretransplant chemoembolization at 1 year (60.8% vs 61.5%) and at 3 years (48.4% vs 53.9%), In group I, three patients developed unex plained severe pneumonia, leading to death very early after liver transplan tation. Marked tumor necrosis (> 50%) was found in 14 cases in group I, In 6 out of these 14 patients, total tumor necrosis was observed. Conclusion: Although preoperative chemoembolization or chemotherapy induced marked tumor necrosis, these patients showed no benefit in survival compar ed to historical controls, and appeared to be at higher risk of developing immediate postoperative infective complications.