Synthesis of imidazo[1,2-a]pyridines as antiviral agents

Authors
Gueiffier, A Mavel, S Lhassani, M Elhakmaoui, A Snoeck, R Andrei, G Chavignon, O Teulade, JC Witvrouw, M Balzarini, J De Clercq, E Chapat, JP
Citation
A. Gueiffier et al., Synthesis of imidazo[1,2-a]pyridines as antiviral agents, J MED CHEM, 41(25), 1998, pp. 5108-5112
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
00222623 → ACNP
Volume
41
Issue
25
Year of publication
1998
Pages
5108 - 5112
Database
ISI
SICI code
0022-2623(199812)41:25<5108:SOIAAA>2.0.ZU;2-K
Abstract
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cyto megalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure- activity relationship is discussed.