Metabolic differences between hearts of patients with aortic valve diseaseand hearts of patients with ischaemic disease

The hypertrophic hearts of patients with aortic valve disease are likely to have metabolic demands different from hearts with ischaemic disease. in th is study we measured the myocardial concentration of ATP, ADP, lactate and 16 different amino acids in left ventricular biopsies collected from patien ts with aortic valve disease and from patients with ischaemic heart disease . Compared to hearts with ischaemic disease, hypertrophic hearts had signif icantly higher concentrations of ATP, but lower concentrations of lactate, branched-chain amino acids and alanine. These differences have important im plications for energy metabolism and protein turnover in the two pathologie s. (C) 1998 Academic Press.