Ferritin concentrations in cerebrospinal fluid (CSF) of 16 patients with gl
ioblastoma were found to be very high (mean, 103.0 ng/mL) relative to 29 pa
tients with viral meningitis and 20 patients with headache (mean concentrat
ions, 5.4 and 4.3 ng/mL respectively). Simultaneous measurement of ferritin
in CSF and serum revealed CSF concentrations exceeding those in serum in 1
1 of 16 patients with glioblastoma (CSF vs. serum ratio, 132.6%), contrasti
ng with very low ratios in patients with meningitis (7.9%) or headache (4.9
%). Ferritin was detected immunocytochemically in tumor cell cytoplasm in a
resected glioblastoma. Thus, ferritin in CSF appears to be produced by gli
oblastoma cells, with a biologic significance requiring further investigati
on.