Leishmaniasis is a chronic-parasitic protozoal disease transmitted by sandf
ly vectors and is endemic in some regions of South America, Asia, Africa an
d Mediterranean countries. This case report describes a British patient who
presented with oral mucosal leishmaniasis and in whom it was also the firs
t sign of HIV disease. We believe it is the first reported case of isolated
oral mucosal leishmaniasis as a presenting feature of otherwise unknown HI
V infection.