Intramolecular cycloadditions of nitrones derived from 1-allyl-2-pyrrolecarbaldehyde as a route to racemic and enantiopure pyrrolizidines and indolizidines

Authors
Arnone, A Broggini, G Passarella, D Terraneo, A Zecchi, G
Citation
A. Arnone et al., Intramolecular cycloadditions of nitrones derived from 1-allyl-2-pyrrolecarbaldehyde as a route to racemic and enantiopure pyrrolizidines and indolizidines, J ORG CHEM, 63(25), 1998, pp. 9279-9284
Citations number
46
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
63
Issue
25
Year of publication
1998
Pages
9279 - 9284
Database
ISI
SICI code
0022-3263(199812)63:25<9279:ICONDF>2.0.ZU;2-N
Abstract
A version of the intramolecular nitrone cycloaddition strategy, using 2-pyr rolecarbaldehyde as starting material, has been developed to synthesize new pyrrolizidines and indolizidines structurally related to biologically acti ve alkaloids. The target molecules have been accessible in racemic as well as enantiopure form.