Purpose: This article describes an infant with a large abdominal mass and h
ypertension
Patient and Methods: A 5-month-old infant girl with diarrhea of 1 week's du
ration and a large right-sided abdominal mass was brought far treatment. Co
mputed tomography of the abdomen revealed a large, generally homogeneous, h
ypodense mass, which compressed the right kidney, resulting in dilatation o
f the right renal collecting system. At surgery, the mass was adherent ante
riorly to the transverse colon and attached by a stalk to the mesentery nea
r the origin of the right colic artery.
Results: Examination of the mass showed an encapsulated lipoblastoma. Cytog
enetic analysis revealed a 46,XX karyotype with a reciprocal translocation
between chromosome 2 and chromosome 8 with breakpoints at q23 and q11.2, re
spectively.
Conclusion: Lipoblastoma is a rapidly growing but benign tumor, which can c
ause severe medical problems by compressing major organs. Cytogenetic analy
sis can reveal translocations involving chromosome 8 band q11.2, which appe
ars to be a specific chromosome marker for lipoblastoma.