Application of standardisation methods to correct the spectral differencesinduced by a fibre optic probe used for the near-infrared analysis of pharmaceutical tablets
E. Bouveresse et al., Application of standardisation methods to correct the spectral differencesinduced by a fibre optic probe used for the near-infrared analysis of pharmaceutical tablets, J PHARM B, 18(1-2), 1998, pp. 35-42
Near infrared spectroscopy has become very popular in the pharmaceutical in
dustry because of many important practical advantages. With the help of pow
erful chemometric techniques, multivariate calibration models are developed
, relating near-infrared spectra to the values to be modelled. However, bec
ause of small instrumental differences between near-infrared spectrometers,
a calibration model can only be used with spectra collected on the same in
strument, which represents a serious limitation for the use of near-infrare
d spectroscopy in the pharmaceutical industry. To deal with this important
problem, a certain number of different standardisation approaches were prop
osed in the literature. In this article, an application of instrument stand
ardisation methods is presented, where two different data measurement modul
es (internal measurement cell and external fibre optic module) of a near-in
frared spectrometer must be standardised for the quantitative determination
of an active compound in pharmaceutical tablets. (C) 1998 Elsevier Science
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