Determination of imidazole antimycotics in creams by supercritical fluid extraction and derivative UV spectroscopy

Authors
Bonazzi, D Cavrini, V Gatti, R Boselli, E Carboni, M
Citation
D. Bonazzi et al., Determination of imidazole antimycotics in creams by supercritical fluid extraction and derivative UV spectroscopy, J PHARM B, 18(1-2), 1998, pp. 235-240
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
18
Issue
1-2
Year of publication
1998
Pages
235 - 240
Database
ISI
SICI code
0731-7085(199810)18:1-2<235:DOIAIC>2.0.ZU;2-8
Abstract
A supercritical fluid extraction (SFE) method was developed for the isolati on of imidazole antimycotic drugs (miconazole, econazole, clotrimazole and bifonazole) from cream preparations. The SFE process involved static (1 min ) and dynamic (4 min) extraction steps using pure and 10% methanol modified carbon dioxide. The SFE step was then followed by derivative UV spectropho tometric analysis. The method proved to be suitable for quality control ass ays of the examined antimycotics in commercial cream formulations. (C) 1998 Elsevier Science B.V. All rights reserved.