Serial volumetric (three-dimensional) intravascular ultrasound analysis ofrestenosis after directional coronary atherectomy

Objectives. We report the use of three dimensional (volumetric) intravascul ar ultrasound (IVUS) analysis to assess serial changes after directional co ronary atherectomy (DCA). Background. Recent serial planar IVUS studies have described a decrease in external elastic membrane (EEM) area following catheter-based intervention as an important mechanism of late lumen renarrowing. Methods. Thirty-one patients with de novo native coronary lesions treated w ith DCA in the Serial Ultrasound Restenosis (SURE) Trial and in Optimal Ath erectomy Restenosis Study (OARS) were enrolled in this study. Serial IVUS w as performed before and after intervention and at 6 months' follow-up. In a subgroup of 18 patients from the SURE trial, IVUS was also performed at 24 h and at 1 month postintervention. Segments, 20-mm-long (200 image slices) , were analyzed using a previously validated three-dimensional, computerize d, automated edge-detection algorithm. The EEM, lumen, and plaque+media (PM = EEM-lumen) volumes were calculated. Results. At follow up, lumen volume was smaller than at postintervention (1 59 +/- 69 mm(3) vs. 179 +/- 49 mm(3), p = 0.0003). From postintervention to follow up, there was a decrease in EEM volume (377 +/- 107 to 352 +/- 125 mm(3), p < 0.0001), but no change in P+M volume (p = 0.52). The Delta lumen volume correlated strongly with Delta EEM volume (r = 0.842, p < 0.0001), but not with Delta P+M volume. In the 18 patients from the SURE Trial, the decrease in lumen and EEM volumes occurred late, between 1 month and 6 mont hs of follow up. Conclusions. Volumetric IVUS analysis demonstrated that late lumen volume l oss following DCA was a result of a decrease in EEM volume. This was a late event, occurring between 1 and 6 months' postintervention. (J Am Coll Card iol 1998;32:1874-80) (C) 1998 by the American College of Cardiology.