Rr. Azar et al., Abciximab in primary coronary angioplasty for acute myocardial infarction improves short- and medium-term outcomes, J AM COL C, 32(7), 1998, pp. 1996-2002
Citations number
34
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objectives. The purpose of this study was to compare the outcome of primary
percutaneous transluminal coronary angioplasty for acute myocardial infarc
tion (MI) when performed with or without the platelet glycoprotein IIb/IIIa
antibody, abciximab.
Background. Abciximab improves the outcome of angioplasty but the effect of
abciximab in primary angioplasty has not been investigated.
Methods. Data were collected from a computerized database. Follow-up was by
telephone or review of outpatient or hospital readmission records.
Results. A total of 182 consecutive patients were included; 103 received ab
ciximab and 79 did not. The procedural success rate was 95% in the two grou
ps. At 30-day follow-up, the composite event rate of unstable angina, reinf
arction, target vessel revascularization and death from all causes was 13.5
% in the group of patients who did not receive abciximab, 4% (p < 0.05) in
the abciximab group and 2.4% (p < 0.05) in the subgroup of patients (n = 87
) who completed the 12-h abciximab infusion. At the end of follow-up (mean
7 +/- 4 months), the composite event rate was 32.4%, 17% (p < 0.05) and 13.
1% (p < 0.01) in these three categories respectively. Abciximab bolus follo
wed by a 12-h infusion was an independent predictor of event-free survival,
in a Cox proportional hazards model (relative risk 0.49; 95% confidence in
terval 0.24 to 0.99; p < 0.05).
Conclusions. Abciximab given at the time of primary angioplasty may improve
the short- and medium-term outcome of patients with acute MI, especially w
hen a 12-h infusion is completed. (J Am Coil Cardiol 1998;32:1996-2002) (C)
1998 by the American College of Cardiology.