Focal mucinosis of the eyelid

Purpose To present a case of focal mucinosis of the eyelid. Patient A male patient of Turkish origin born in 1982 desired therapy in 19 95 for an asymptomatic tumour of the left medial upper lid which had been p resent probably since birth. The tumour was reduced with argon laser photoc oagulation. Fourteen months later, in 1997, the tumour had enlarged so that a surgical excision was performed which histologically was interpreted as an unspecific inflammation. In 1998, the tumour had grown again at the orig inal site, and there were additional three pedunculated tumours nearby at t he lid margin. All tumours were surgically excised. Histology showed empty spaces in the upper dermis which contained some connective fibers, benign a ppearing fibroblasts and some leukocytes. The PAS-reaction and S100-immunoh istology were negative while the lesion stained positive for alcianblue. Th e epidermis was intact. A diagnosis of a focal mucinosis of the eyelid was established. Conclusions Focal mucinosis of the eyelid seems to be exceedingly rare. It is probably caused by a local overproduction of hyaluronic acid of unknown etiology. Our patient demonstrates that focal mucinosis might perhaps be co ngenital. Moreover it may recur if excision is not complete. Focal mucinosi s should be included in the differential diagnosis of long-lasting, asympto matic lid tumours.