GD(3) and GM(2) synthase activities in rat testes during the period of sexual development

Authors
Gamallo, JLGT Trindade, VMT Bernard, EA
Citation
Jlgt. Gamallo et al., GD(3) and GM(2) synthase activities in rat testes during the period of sexual development, LIPIDS, 33(11), 1998, pp. 1089-1092
Citations number
29
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
LIPIDS
ISSN journal
00244201 → ACNP
Volume
33
Issue
11
Year of publication
1998
Pages
1089 - 1092
Database
ISI
SICI code
0024-4201(199811)33:11<1089:GAGSAI>2.0.ZU;2-3
Abstract
Activities of two key enzymes of gangliosides biosynthesis were determined in rat testes during development. GD(3) synthase activity was low and showe d small variations with age. GM(2) synthase activity increased 10-fold in t estes from 10- to 30-d-old animals, showing a maximum activity at 30 d, fol lowed by a small decrease until 45 d and then a constant activity up to adu lthood. These developmental changes in the activity of both glycosyltransfe rases were related to the increasing complexity in the ganglioside pattern observed in rats testes during the period of sexual development.