A RAPID AND REVERSIBLE CHANGE IN DOPAMINE TRANSPORTERS INDUCED BY METHAMPHETAMINE

Authors
FLECKENSTEIN AE METZGER RR GIBB JW HANSON GR
Citation
Ae. Fleckenstein et al., A RAPID AND REVERSIBLE CHANGE IN DOPAMINE TRANSPORTERS INDUCED BY METHAMPHETAMINE, European journal of pharmacology, 323(2-3), 1997, pp. 9-10
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
323
Issue
2-3
Year of publication
1997
Pages
9 - 10
Database
ISI
SICI code
0014-2999(1997)323:2-3<9:ARARCI>2.0.ZU;2-B
Abstract
Because high doses of methamphetamine promote free radical formation, and striatal dopamine transporters are rapidly inactivated by oxidativ e events, we determined the effect of a single high dose of methamphet amine on dopamine transporter activity in striatal synaptosomes. One h our after methamphetamine administration, dopamine uptake decreased by 48%. This dramatic decline was totally reversed by 24 h after treatme nt. These findings suggest that methamphetamine reversibly decreases d opamine transporter activity by oxidative mechanisms.