The focus of this article is on early recognition and rapid diagnosis of so
me of the most challenging, complex, and difficult to treat and manage auto
immune blistering mucocutaneous diseases. These diseases are potentially fa
tal if not recognized early or if treated inappropriately or incorrectly. T
he emphasis has been placed on those seen in adults and on morphologic reco
gnition rather than details of therapeutic management. Blistering diseases
in children are frequently inherited disorders due to genetic abnormalities
found in the structure and function of specific molecules. These have been
mentioned only to facilitate the reader to identify them because treatment
or mechanism of their pathogenesis is beyond the scope and purpose of this
article.