Profound symptomatic bradycardia associated with combined mibefradil and beta-blocker therapy

Authors
Rogers, IR Prpic, R
Citation
Ir. Rogers et R. Prpic, Profound symptomatic bradycardia associated with combined mibefradil and beta-blocker therapy, MED J AUST, 169(8), 1998, pp. 425-427
Citations number
6
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
MEDICAL JOURNAL OF AUSTRALIA
ISSN journal
0025729X → ACNP
Volume
169
Issue
8
Year of publication
1998
Pages
425 - 427
Database
ISI
SICI code
0025-729X(19981019)169:8<425:PSBAWC>2.0.ZU;2-B
Abstract
We report two cases where the addition of mibefradil to long term beta-bloc ker therapy in managing hypertension produced profound symptomatic bradycar dia requiring cardiac pacing. Reports of a number of interactions between m ibefradil and other cardioactive drugs have now led to its withdrawal from the market worldwide.