D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine hasno effect
P. Riekkinen et al., D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine hasno effect, NEUROREPORT, 9(16), 1998, pp. 3647-3651
THE present study examined the efficacy of single and combined treatments w
ith an anticholinesterase, tetrahydroaminoacridine, nicotine and a glycine-
B site partial agonist, D-cycloserine, in alleviating the water maze revers
al learning defect induced by a medial septal lesion. D-cycloserine (3 and
10 mg/kg) improved reversal learning. Tetrahydroaminoacridine (1 and 3 mg/k
g) and nicotine (0.1 and 0.3 mg/kg) had no effect on reversal learning. A c
ombination of tetrahydroaminoacridine 3 mg/kg or nicotine 0.3 mg/kg and D-c
ycloserine 10 mg/kg was not more effective than D-cycloserine 10 mg/kg alon
e in improving reversal learning. This suggests that stimulation of NMDA me
chanisms may more effectively improve in medial septal-lesioned rats revers
al learning processes than stimulation of cholinergic activity. NeuroReport
9: 3647-3651 (C) 1998 Lippincott Williams & Wilkins.