The graft-versus-host disease reaction is an immunologic consequence result
ing from the grafting of immunocompetent cells from one individual to an im
munocompromised host. The oral manifestations of this disease process inclu
de severe oral pain, xerostemia, ulcerative lesions, and mucositis. With ap
propriate history and diagnostic testing, these lesions can be differentiat
ed from other oral diseases having similar clinical appearance.