The hemolytic-uremic syndrome (HUS) typically presents in toddlers or older
children after an episode of bloody diarrhea caused by Escherichia coli 01
57:H7. However, numerous "atypical" presentations have been described, incl
uding familial cases. Here we describe what we believe to be the first repo
rt of familial HUS in a premature infant during the neonatal period.