P. Grammatico et al., Cytogenetic follow-up in a case with a primary cutaneous melanoma and fivemetastatic lesions, PIGM CELL R, 11(5), 1998, pp. 314-319
Cytogenetic analyses conducted on several cases of melanoma have contribute
d to the identification of the chromosomal regions where the sequences resp
onsible for malignant transformation and the evolution of this tumor are pr
obably located. With regard to these problems, it is very important to have
the possibility to analyze, through the use of cytogenetics, both the prim
ary melanoma and the metastatic lesions from the same patient. We present a
case in which the primary melanoma and five different metastases were stud
ied by using cytogenetics.
The primary tumor showed an inversion of chromosome I where the p36 region,
often proposed in literature as the location of a melanoma susceptibility
gene, was involved.
Three cutaneous and one lymphonodal metastases presented the same nine clon
al chromosomal aberrations. In particular; one is a further rearrangement o
f the marker present in the primary tumor; another is a deletion of the 9p2
1pter region in which the p16 gene is located.
Our results can provide a contribution to the hypothesis of the location of
a candidate gene for melanoma in the 1p36 region and can also underscore t
he role of the 9p21 region in the progression of melanoma.