S. Yumoto et al., AL-26 UPTAKE AND ACCUMULATION IN THE RAT-BRAIN, Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, 123(1-4), 1997, pp. 279-282
To investigate the cause of Alzheimer's disease (senile dementia), Al-
26 incorporation in the rat brain was studied by accelerator mass spec
trometry (AMS). When Al-26 was injected into healthy rats, a considera
ble amount of Al-26 entered the brain (cerebrum) through the blood-bra
in barrier 5 days after a single injection, and the brain Al-26 level
remained almost constant from 5 to 270 days. On the other hand, the le
vel of Al-26 in the blood decreased remarkably 75 days after injection
. Approximately 89% of the Al-26 taken in by the brain cell nuclei bou
nd to chromatin. This study supports the theory that Alzheimer's disea
se is caused by irreversible accumulation of aluminium (Al) in the bra
in, and brain cell nuclei.