Cardiovascular and respiratory effects of epidural administration of lidocaine, fentanyl and morphine in dogs anaesthetized with halothane

The present study was conducted to investigate the effects of epidural admi nistration of Lidocaine, Fentanyl and Morphine on the cardiovascular and re spiratory systems in the dogs anaesthetized with Halothane. A mixture of 0. 26 ml/kg 2% Lidocaine, 0.05 mg Fentanyl and 2 mg Morphine was introduced ep idurally in 6 clinically healthy dogs anaesthetized with Halothane. The epi dural administration of the mixture resulted in significant reduction in sy stolic blood pressure (SBP) at the intervals from 15 to 60 min (P< 0.05). C ardiac output (CO) and cardiac index (CI) decreased within the interval fro m 15 to 90 min (P< 0.05). The changes in the respiratory parameters were in significant. In conclusion, the supplementary epidural application of a mixture of Lidoc aine, Fentanyl and Morphine is a safe and effective method for achieving re liable anaesthesia with minimal respiratory and moderate cardiovascular sid e effects.