Neuropathy as an extrahepatic manifestation of chronic liver diseases

Gastrointestinal motor disturbances and various cardiovascular symptoms are the characteristic features of autonomic neuropathy. Autonomic and sensory neuropathy has been described in chronic alcoholic liver diseases. Cardiov ascular autonomic reflex tests as the gold standard for autonomic neuropath y and measuring of thresholds for constant current electric sine wave stimu lation by neurometer were used for measuring sensory neuropathy in patients with chronic liver diseases of different etiology. Autonomic and sensory n europathy was also observed in non-alcoholic liver diseases. We proved that there is a correlation between autonomic neuropathy and prolongation of co rrected QT interval in chronic liver diseases. We claim that autonomic neur opathy may have a role to play in the development of hyperdynamic circulati on and portal hypertension in chronic liver diseases.