Activity of quinolones against viridans group streptococci isolated from blood cultures of patients with haematological malignancy

Citation
Kg. Kerr et al., Activity of quinolones against viridans group streptococci isolated from blood cultures of patients with haematological malignancy, SUPP CARE C, 7(1), 1999, pp. 28-30
Citations number
14
Categorie Soggetti
Health Care Sciences & Services
Journal title
SUPPORTIVE CARE IN CANCER
ISSN journal
09414355 → ACNP
Volume
7
Issue
1
Year of publication
1999
Pages
28 - 30
Database
ISI
SICI code
0941-4355(199901)7:1<28:AOQAVG>2.0.ZU;2-3
Abstract
Use of fluoroquinolones for antimicrobial prophylaxis during neutropenia is often cited as a significant predisposing factor for viridans group strept ococcus (VGS) bacteraemia. Newer compounds in this class are reputed to hav e enhanced activity against Gram-positive bacteria, and we determined the m inimal inhibitory concentrations (VGS) for ciprofloxacin and three of the n ewer compounds: trovafloxacin, fleroxacin and clinafloxacin, against 44 iso lates of VGS. On a gravimetric basis, clinafloxacin was most active (MIC90 0.19 mg/l), whereas ciprofloxacin and fleroxacin were the least active (bot h MIC90 16 mg/l). Clinafloxacin warrants further study as an agent of proph ylaxis against bacterial infection in neutropenic patients.