Jh. Yim et al., Prospective study of the utility of somatostatin-receptor scintigraphy in the evaluation of patients with multiple endocrine neoplasia type 1, SURGERY, 124(6), 1998, pp. 1037-1042
Background. Neuroendocrine tumors (NETs) are a potentially lethal component
of multiple endocrine neoplasia type 1 (MEN 1). Somatostatin receptor scin
tigraphy (SRS) can be used to localize NETs and evaluate patients for extra
duodenopancreatic disease; its utility in managing MEN 1 is undefined.
Methods. All patients with MEN 1 evaluated by SRS from April 1994 to Novemb
er 1997 are reported. SRS findings were correlated with other imaging studi
es and operative findings.
Results. Thirty-seven SRS studies were performed in 29 patients with MEN I.
SRS identified occult tumor in 36 % (4/11) of patients with only biochemic
al evidence of NET; 2 patients went on to resection. SRS showed tumor in 79
% (15/19) of patients with computed tomography (CT)-demonstrated tumor; 30
% (6/20) of the SRS lesions were occult on CT. Conversely, 55 % (16/29) of
CT-identified lesions were occult on SRS. SRS found distant disease in 21%
(6/29) of patients. In patients who had previous operations, SRS found tumo
r in 40% (4/10) of patients, again with both new positive and false-negativ
e results compared with other imaging SRS also had 3 important false-positi
ve results, including 2 patient who had laparotomy with no tumor identified
.
Conclusions. SRS is useful in identifying otherwise occult NETs in patients
with MEN 1 and can substantially alter management. However SRS also has si
gnificant false-positive and false-negative results that demand correlation
with other studies.