Thionucleoside disulfide cross-linked duplex DNA

Authors
Coleman, RS McCary, JL Perez, RJ
Citation
Rs. Coleman et al., Thionucleoside disulfide cross-linked duplex DNA, TETRAHEDR L, 40(1), 1999, pp. 13-16
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
1
Year of publication
1999
Pages
13 - 16
Database
ISI
SICI code
0040-4039(19990101)40:1<13:TDCDD>2.0.ZU;2-7
Abstract
A strategy for covalent cross-linking of duplex oligonucleotides is describ ed, and is based on a direct base-to-base disulfide bond formed by iodine o xidation of two appropriately positioned thionucleoside bases. Cross-link f ormation between 4-thio-2'-deoxyuridine and 6-thio-2'-deoxyinosine is demon strated in three sequence contexts (3' to 3', 5' to 5', or opposed). (C) 19 98 Elsevier Science Ltd. All rights reserved.