Solid-phase amino-zinc-enolate cyclization for the synthesis of 3-substituted prolines

Authors
Karoyan, P Triolo, A Nannicini, R Giannotti, D Altamura, M Chassaing, G Perrotta, E
Citation
P. Karoyan et al., Solid-phase amino-zinc-enolate cyclization for the synthesis of 3-substituted prolines, TETRAHEDR L, 40(1), 1999, pp. 71-74
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
1
Year of publication
1999
Pages
71 - 74
Database
ISI
SICI code
0040-4039(19990101)40:1<71:SACFTS>2.0.ZU;2-6
Abstract
Preparation of 3-substituted prolines was achieved by extension to Solid Ph ase Organic Synthesis (SPOS) of the amino-zinc-enolate cyclization we have recently described.(1 )Functionalizations of proline at C-3 were considered by nucleophilic substitutions of an iodo derivative obtained on the resin. (C) 1998 Elsevier Science Ltd. All rights reserved.