The formation of the lignans in liverworts, Jamesoniella autumnalis and Lop
hocolea heterophylla was investigated. Feeding experiment of [8-H-2] caffei
c acid (4) on axenic cultures of J. autumnalis has shown that jamesopyrone
(2) and scapaniapyrone (3) were derived from the coupling of two intact caf
feic molecules. Studies in a cell-free system of J. autumnalis and L. heter
ophylla have shown the formation of (+/-)- 1 from 4. (C) 1998 Elsevier Scie
nce Ltd. All rights reserved.