A practical preparation of diisopropyl phosphoryl protected amino acids.

Authors
Brands, KMJ Wiedbrauk, K Williams, JM Dolling, UH Reider, PJ
Citation
Kmj. Brands et al., A practical preparation of diisopropyl phosphoryl protected amino acids., TETRAHEDR L, 39(52), 1998, pp. 9583-9586
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
39
Issue
52
Year of publication
1998
Pages
9583 - 9586
Database
ISI
SICI code
0040-4039(199812)39:52<9583:APPODP>2.0.ZU;2-A
Abstract
N-Diisopropyl phosphoryl protected amino acids can be prepared in high yiel d and without racemization by slow addition of sodium hypochlorite to a sol ution of the amino acid and diisopropylphosphite in water while carefully m aintaining a constant pH via the addition of sodium hydroxide. (C) 1998 Els evier Science Ltd. All rights reserved.