Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

Authors
Gopi, HN Babu, VS
Citation
Hn. Gopi et Vs. Babu, Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust, TETRAHEDR L, 39(52), 1998, pp. 9769-9772
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
39
Issue
52
Year of publication
1998
Pages
9769 - 9772
Database
ISI
SICI code
0040-4039(199812)39:52<9769:SOPEFA>2.0.ZU;2-T
Abstract
Coupling of Fmoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried o ut in an organic medium. The necessity of using an inorganic base like NaHC O3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. Th e coupling is reasonably fast, clean, racemization free and high yielding. (C) 1998 Elsevier Science Ltd. All rights reserved.