Intramolecular transamidation of beta-lactams as a means for the enzymaticcontrol of ring opening: Effect of substituents on the rate of reaction

Authors
Banfi, L Guanti, G Rasparini, M
Citation
L. Banfi et al., Intramolecular transamidation of beta-lactams as a means for the enzymaticcontrol of ring opening: Effect of substituents on the rate of reaction, TETRAHEDR L, 39(51), 1998, pp. 9539-9542
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
39
Issue
51
Year of publication
1998
Pages
9539 - 9542
Database
ISI
SICI code
0040-4039(199812)39:51<9539:ITOBAA>2.0.ZU;2-G
Abstract
A series of simple monocyclic p-lactams bearing side-chains, containing ami no groups, have been synthesized, and the rate of their intramolecular tran samidation studied. Protection of the amino group with an enzymatically cle avable group, allows us to selectively control the ring enlargement process . (C) 1998 Elsevier Science Ltd. All rights reserved.