Se. Adunyah et al., EVIDENCE FOR THE INVOLVEMENT OF LCK AND MAP KINASE (ERK-1) IN THE SIGNAL-TRANSDUCTION MECHANISM OF INTERLEUKIN-15, Biochemical and biophysical research communications, 232(3), 1997, pp. 754-758
Human IL-15 is a cytokine expressed by a variety of tissues and cells
including myeloid progenitor cells and monocytes. It shares biologic p
roperties of IL-2 and utilizes the beta subunit of the IL-BR, IL-15 re
gulates proliferation of activated B and Mt cells and stimulates chemo
attraction in blood T-lymphocytes, effects which are inhibited by an a
nti-IL-SR beta antibody. Because little is known about the mechanism(s
) by which IL-15 signal is transduced, this study was conducted to ide
ntify some of the key molecules involved in IL-15-induced signaling ca
scade(s). We report that IL-15 induces tyr phosphorylation of the p75I
L-2R beta and p64IL-2R gamma subunits and She. Also, it activates both
p561ck and MAPK (ERK-1). These results strongly suggest that LCK and
MAPK may play vital roles in mediation of cellular activation by IL-15
. (C) 1997 Academic Press.