C. Miyazaki et al., Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin, VACCINE, 17(3), 1999, pp. 245-251
The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH)
skin reactions in guinea pigs immunized with live BCG or heat killed Mycob
acterium tuberculosis H37Rv, and also induced lymphocyte proliferative resp
onse in mice immunized with ribosomes. In contrast, neither ribosomal prote
ins nor RNA alone induced both DTH skin reactions and lymphocyte proliferat
ive responses. Particle form consisted of ribosomal proteins and RNAs might
be absolutely required for the activation of immune responses. (C) 1998 El
sevier Science Ltd. All rights reserved.