Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin

Citation
C. Miyazaki et al., Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin, VACCINE, 17(3), 1999, pp. 245-251
Citations number
17
Categorie Soggetti
Veterinary Medicine/Animal Health",Immunology
Journal title
VACCINE
ISSN journal
0264410X → ACNP
Volume
17
Issue
3
Year of publication
1999
Pages
245 - 251
Database
ISI
SICI code
0264-410X(19990121)17:3<245:HIRTRR>2.0.ZU;2-5
Abstract
The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycob acterium tuberculosis H37Rv, and also induced lymphocyte proliferative resp onse in mice immunized with ribosomes. In contrast, neither ribosomal prote ins nor RNA alone induced both DTH skin reactions and lymphocyte proliferat ive responses. Particle form consisted of ribosomal proteins and RNAs might be absolutely required for the activation of immune responses. (C) 1998 El sevier Science Ltd. All rights reserved.