KIDNEY BEAN AND SOYBEAN LECTINS CAUSE ENZYME-SECRETION BY PANCREATIC ACINI IN-VITRO

Authors
GRANT G HENDERSON LT EDWARDS JE EWAN EC BARDOCZ S PUSZTAI A
Citation
G. Grant et al., KIDNEY BEAN AND SOYBEAN LECTINS CAUSE ENZYME-SECRETION BY PANCREATIC ACINI IN-VITRO, Life sciences, 60(18), 1997, pp. 1589-1595
Citations number
24
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
60
Issue
18
Year of publication
1997
Pages
1589 - 1595
Database
ISI
SICI code
0024-3205(1997)60:18<1589:KBASLC>2.0.ZU;2-K
Abstract
The responses of pancreas acini from Hooded-Lister rats to kidney bean E(2)L(2) lectin or soybean agglutinin have been studied in vitro. Bot h lectins induced secretion of alpha-amylase from acini in a dose depe ndent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lect ins in vitro was significantly altered by the age and sex of the rats from which the acini were derived.