Objectives - To investigate if the EEG response at moderate altitude may pr
edict a person's tolerance to acute mountain sickness (AMS). Materials and
methods - Frequency analysis (QEEG) of tape-recorded ambulatory EEG was per
formed in 6 climbers during a mountaineering expedition to 7546 m above sea
level. The QEEG response in climbers, measured at sea level, at 4500 m, an
d at 1800 m 1-4 days after maximal altitude exposure, was compared to the c
hange observed during consecutive sea level recordings in 10 control subjec
ts. Results - Three climbers experienced slight (grade 1) AMS symptoms both
at 4500 m and at maximal altitude exposure (Group 1). Three other climbers
(Group 2) had no symptoms at 4500 m, but they developed AMS (grades 1, 2,
or 3) at maximal altitude. Alpha amplitudes were higher at 4500 m in group
1 climbers, while it was lower in group 2 climbers compared to the sea leve
l recording. Significant time x group interactions in ANOVA were found for
delta (P = 0.005), theta (P = 0.001) and alpha (P=0.001) amplitude, indicat
ing that QEEG amplitudes decreased significantly at high altitude in group
2 climbers. Conclusion - The QEEG response to moderate hypobaric hypoxia is
not uniform, but the direction of QEEG amplitude change, particularly in t
he alpha band, may possibly predict the risk of developing AMS.