Carbohydrate-deficient transferrin: Marker of actual alcohol consumption or chronic alcohol misuse?

Carbohydrate-deficient transferrin (CDT) is a useful indicator of excessive alcohol consumption with higher sensitivity and specificity than other mar kers that are used. In the present study, CDT was analysed in 161 patients hospitalized in a surgical ward to evaluate whether history of drinking and chronic alcohol misuse are important determinants of CDT elevations. Fifty -one of the patients were diagnosed as alcohol-dependent and they all repor ted a long history of alcohol abuse. Several of these, as well as many of t he non-dependent patients, reported a high, recent alcohol consumption (gre ater than or equal to 60 g/day for the previous 2 weeks). CDT performed bet ter in detecting patients with alcohol dependency than in detecting patient s with high alcohol consumption irrespective of dependency, showing higher sensitivity (47 vs 37%), likelihood ratio (4.7 vs 3.4), and a statistically significant difference in the receiver-operating characteristic curve area s (P = 0.04 in a two-tailed comparison test). In two subgroups, one with al cohol-dependent and one with non-dependent patients, consuming similar amou nts of alcohol (range: 60-170 g/day), the sensitivity of CDT was 52 and 5%, respectively. We conclude that CDT is a better marker for patients with ch ronic alcohol misuse than as a marker for high actual alcohol consumption a lone.