Acquired factor VIII inhibitors - Successful treatment with an oral outpatient regimen

A rare cause of a spontaneous, life threatening coagulopathy in adults Is t he development of autoantibodies to factor VIII. We recently had the opport unity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. A il patients had a complete response to treatment. The median time to respon se was three weeks. Durable remissions were achieved, making this oral regi men an acceptable treatment for this disorder. (C) 1999 Wiley-Liss, Inc.