Exposure to allopurinol and the risk of cataract extraction in elderly patients

Objective: To determine whether exposure to allopurinol is associated with an increased risk of cataract extraction in elderly patients. Methods: We conducted a case-control study using data from the Quebec unive rsal health insurance program for all elderly patients. The 3677 cases were patients with a cataract extraction between 1992 and 1994. The 21 868 cont rols were randomly selected among patients not diagnosed with cataract and matched to cases on the date of the extraction. We determined the odds rati o of cataract extraction according to the cumulative dose and duration of a llopurinol use relative to nonusers, using conditional logistic regression analysis. The analysis was adjusted for the effects of age, sex, diabetes m ellitus, hypertension, glaucoma, and ophthalmic and oral corticosteroid exp osure. Results: A cumulative dose of allopurinol of more than 400 g or a duration of use of longer than 3 years were associated with an increased risk of-cat aract extraction, with odds ratios of 1.82 (95% confidence interval [CI], 1 .18-2.80) and 1.53 (95% CI, 1.12-2.08), respectively. No increase in risk w as observed for lower cumulative doses or shorter exposure periods. Conclusion: Long-term administration of allopurinol increases the risk of c ataract extraction in elderly patients.