This report summarises the discussions of a workshop sponsored by the Europ
ean Cosmetics, Toiletries and Perfumery Association (COLIPA). The workshop
discussed the state-of-the-art of eye irritancy testing, and made recommend
ations as to the best ways in which to validate alternatives to the Draize
eye irritation test. The importance of understanding the mechanisms of eye
irritation, particularly when attempting to improve in vitro prediction of
in vivo eye irritancy, was also emphasised.