Production of Rifamycin using Amycolatopsis mediterranei (MTCC14)

Production of Rifamycin with Amycolatopsis mediterranei (MTCC14) was studie d using carbon and locally available cheaper nitrogen sources. A. Mediterra nei gave initial yield of 650 mg/l with standard fermentation medium. This was improved to 1400 mg/l by using various Carbon, Nitrogen sources and opt imizing various cultural conditions. Glucose, Ammonium sulphate and combina tion of soya bean and pea nut meals were found to induce more Rifamycin pro duction in 7 days with a pH of 7.2, temperature 28 degrees C.