EVALUATION OF EXPERIMENTAL THERAPEUTICS IN A NEW MOUSE MODEL OF HELICOBACTER-FELIS UTILIZING 16S RIBOSOMAL-RNA POLYMERASE CHAIN-REACTION FOR DETECTION

Background: A new mouse model of Helicobacter felis infection, which m imics the human infection observed with H. pylori, has recently been d eveloped utilizing polymerase chain reaction (PCR) based on the 16S rR NA gene sequence for detection of infection. Methods: We tested severa l therapeutic regimens in this model, including some currently utilize d in the clinic and some shown ineffective in the clinic. Results: The therapeutic results obtained by PCR with this model are consistent wi th results observed in the published human H. pylori clinical trials a nd also with results obtained in another H. felis mouse model utilizin g culture and histology. Conclusions: These results support further us e of this new model in screening for new therapeutic regimens for the management of Helicobacter disease.