Dysregulation of trace element composition in ovariectomized cynomolgus monkey bones

One of the challenging issues in modern biomedical science is the increasin g number of osteoporosis patients due to the expansion of elderly populatio ns. Among aging-related pathogenic changes, alterations in bone function an d skeletal pathogenesis is a particularly important issue of concern. Osteo porosis is one of the most serious bone-related pathogenic states, as it ca uses serious loss of quality of Life. Alterations in estrogen levels in acc ordance with aging are one of the key risk factors for osteoporosis. Comple xed estrogen actions on bones can be traced by analyzing bone mineral compo nents, as those elements accumulate as mineral complexes, reflecting the co ntext of multiple cellular reactions such as bone resorption/osteogenesis. We have analyzed bone trace element composition in ovariectomized (OVX-trea ted) Cynomolgus monkey models in this study. In order to gain insights into the effects of such defects on bone trace element composition, inductively coupled plasma atomic emissions spectrometry (ICP-AES) analysis was perfor med. Marked changes in bone trace element levels were found in vertebral bo nes of OVX-treated Cynomolgus monkeys. An assessment of these trace element spectra in OVX model animals is discussed. These results could provide use ful markers for understanding the physiological states of bones in postmeno pausal women.