Authors
Citation
R. Lavilla et al., Vicinal diamination of 1,4-dihydropyridines, CHEM COMMUN, (24), 1998, pp. 2715-2716
Citations number
18
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345
→ ACNP
Issue
24
Year of publication
1998
Pages
2715 - 2716
Database
ISI
SICI code
1359-7345(199812):24<2715:VDO1>2.0.ZU;2-2
Abstract
Electrophilic interaction of iodine with N-aIkyl-1, 4-dihydropyridines 1 in
the presence of secondary amines stereoselectively leads to the correspond
ing trans-2,3-diamino-1,2,3,4-tetrahydropyridines 2 in satisfactory yields
(79-94%); the method allows the synthesis of piperidine, pyrrolidine, morph
oline and piperazine derivatives.