Serotype distribution and prevalence of resistance to benzylpenicillin in three representative populations of Streptococcus pneumoniae isolates from the coast of Kenya

As surveillance data from sub-Saharan Africa are few, three representative populations of Streptococcus pneumoniae isolates were examined in Kenya for serotype distribution and Etest minimum inhibitory concentrations (MICs) o f benzylpenicillin: (1) 75 lung aspirate or blood culture isolates from 301 consecutive adult patients with pneumonia, (2) 112 invasive isolates from continuous pediatric inpatient surveillance over 4 years, and (3) 97 nasoph aryngeal isolates from systematically selected sick children. The proportio ns with benzylpenicillin MICs of greater than or equal to 0.1 mu g/ML were 0.27, 0.29, and 0.47, respectively, Vaccine-related serotypes accounted for 96% of invasive isolates from children and 90% of those from human immunod eficiency virus (HIV)-seropositive adults. Serotype 1 accounted for 44% of pneumococci from HIV-seronegative patients but only 5% of those from HIV-se ropositive patients (P = .0002). Of serotype 1 isolates, 98% were susceptib le to benzylpenicillin, but serogroups 13, 14, 19, and 23 were strongly ass ociated with an MIC of greater than or equal to 0.1 mu g/mL.